Ischaemic heart disease and cholesterol There's more to heart disease than cholesterol

Antioxidants, cholesterol, and ischaemic heart disease: CHAOS or confusion?

Vasopressin and ischaemic heart disease: more than coronary vasoconstriction?

During advanced vasodilatory shock, arginine vasopressin (AVP) is increasingly used to restore blood pressure and thus to reduce catecholamine requirements. The AVP-related rise in mean arterial pressure is due to systemic vasoconstriction, which, depending on the infusion rate, may also reduce coronary blood flow despite an increased coronary perfusion pressure. In a murine model of myocardial...

Cholesterol: from heart attacks to Alzheimer's disease.

The accumulation and aggregation of the amyloid-beta peptide (Abeta) in the brain are important contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of Abeta is a potentially important treatment strategy. Recent work on the metabolism of Abeta has identified several cellular proteins and proteases that collectively promote or prevent the generation of Abeta. I...

Coffee, cholesterol, and coronary heart disease.

Probably the main obstacle to successfully treating obesity is the social attitudes of obese patients and their doctors. Severely obese people often have low self esteem and excessively optimistic expectations of each new treatment. This attitude sets traps for the doctor, who may say that the problem is trivial or easily solved or incurable, none of which is true. Virtually all obese patients ...

Sunlight, cholesterol and coronary heart disease.

We investigated the relationship between geography and incidence of coronary heart disease, looking at deficiency of sunlight and thus of vitamin D as a factor that might influence susceptibility and thus disease incidence. Sunlight deficiency could increase blood cholesterol by allowing squalene metabolism to progress to cholesterol synthesis rather than to vitamin D synthesis as would occur w...